Announcing two new gene level annotators from the Network of Cancer Genes & Healthy Drivers. The Network of Cancer Genes (NCG) is a curated, open-access resource that collects genes whose somatic alterations are reported to drive either cancer evolution or clonal expansion in non-cancer tissues. In addition to driver-gene labels, NCG annotates a broad set of gene systems-level properties including duplicability, evolutionary origin, expression breadth, essentiality, protein-network topology, miRNA regulation, and germline constraint.
The NCG Cancer Drivers annotator focuses on genes with known or predicted driver roles in cancer, along with cancer-context labels such as organ system, primary site, and cancer type. It also includes driver-role annotations from the Cancer Gene Landscape, Saito, and the NCG themselves. It also includes a panel of systems-level properties that distinguish many cancer drivers from other genes.
The NCG Healthy Drivers annotator focuses on genes whose somatic alterations have been reported to drive clonal expansion in non-cancer tissues. These genes are called Healthy Drivers in NCG because they can promote somatic evolution in normal tissues without necessarily causing malignant transformation. The annotator provides information about the affected organ systems, tissue types, and tissue locations, as well as the systems-level properties of the genes.
Both annotators are live on the OpenCRAVAT Server today.
